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Compounds isolated from Salinispora arenicola of the Gulf of California, México

Authors

CORRESPONDING

Irma E. Soria-Mercado

iesoria@uabc.edu.mx

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Facultad de Ciencias Marinas, Universidad Autónoma de Baja California, km 103 Carretera Tijuana-Ensenada, Baja California, México

Ana M. Íñiguez-Martínez

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Facultad de Ciencias Marinas, Universidad Autónoma de Baja California, km 103 Carretera Tijuana-Ensenada, Baja California, México

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Centro Universitario de la Costa, Universidad de Guadalajara, Av. Universidad de Guadalajara No. 203, Puerto Vallarta, Jalisco, México

Faviola Cardoso-Martínez

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Facultad de Ciencias Marinas, Universidad Autónoma de Baja California, km 103 Carretera Tijuana-Ensenada, Baja California, México

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Instituto de Productos Naturales y Agrobiología, C.S.I.C., Av. Astrofísico F. Sánchez, 3. La Laguna, 38206, Tenerife, España

José de la Rosa

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Instituto de Productos Naturales y Agrobiología, C.S.I.C., Av. Astrofísico F. Sánchez, 3. La Laguna, 38206, Tenerife, España

Mercedes Cueto

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Instituto de Productos Naturales y Agrobiología, C.S.I.C., Av. Astrofísico F. Sánchez, 3. La Laguna, 38206, Tenerife, España

Ana Díaz-Marrero

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Instituto de Productos Naturales y Agrobiología, C.S.I.C., Av. Astrofísico F. Sánchez, 3. La Laguna, 38206, Tenerife, España

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Instituto Universitario de Bioorgánica AG, Centro de Investigaciones Biomédicas de Canarias (CIBICAN), Universidad de La Laguna, Av. Astrofísico F. Sánchez, 2, 38206. La Laguna, Tenerife, España

José Darias

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Instituto de Productos Naturales y Agrobiología, C.S.I.C., Av. Astrofísico F. Sánchez, 3. La Laguna, 38206, Tenerife, España

Amayaly Becerril-Espinosa

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Facultad de Ciencias Marinas, Universidad Autónoma de Baja California, km 103 Carretera Tijuana-Ensenada, Baja California, México

Luis J. Plata-Rosas

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Centro Universitario de la Costa, Universidad de Guadalajara, Av. Universidad de Guadalajara No. 203, Puerto Vallarta, Jalisco, México

Abstract

The marine actinobacterium AMS370, identified as Salinispora arenicola by 16S rRNA amplified gene comparison, was isolated from sediments of the Gulf of California, Mexico. From its semi-polar extract, 8 known compounds were isolated: 4-Hydroxy-phenyl acetic acid (1), 5-Methyl-2-methylene-2,3-dihydro-1H-pyrimidin-4-one (2), 1H-Pyrimidine-2,4-dione (3), 3-amino-5-hydroxy-benzoic acid (4), 2-(4-Amino-imidazol-[4,5-d]pyridazin-1-yl)-5-hydroxymethyl-4-methyl-tetrahydro-furan-3-ol (5), 3-(4-Hydroxy-phenyl)-acrylic acid methyl ester (6), 3-Benzyl-6-isobutyl-piperazine-2,5-dione (7) and 5,8-epidioxy-(22E,24R)-ergosta-6,22-dien-3-ol (Ergosterol peroxide) (8). The chemical identification was performed by comparison of their NMR spectra against the NMR spectra of the original compounds. This is the first time that compound 4 is reported as a natural product obtained from the Salinisporagenus. The crude extract and all the fractions obtained were tested for antibiotic activity against Bacillus cereusEscherichia coliEnterococcus faecalis, Klebsiella pneumoniae, Proteus mirabilisStaphylococcus aureusSalmonella sp. and antifungic activity against Candida albicans. Also, breast cancer (MCF-7), cervical cancer (HeLa) and colorectal cancer cell lines (HCT-116) were tested to determine their cytotoxic activity. Only the semi-polar crude extract and its fractions 5.1 and 5.2 were active against Klebsiella pneumoniae and Staphylococcuaureus.

Key words

Marine actinobateria, antibacterial activity, cytotoxic activity, Gulf of California

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