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Inter-annual variability of oceanographic conditions and phytoplankton in Valparaíso Bay (~33°S), central Chile

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Effect of nitrate and irradiance on fatty acid production in microalgae cultivated for feeding larvae and broodstock conditioning in batch culture

Evaluation of antimycobacterial activity from marine and freshwater microalgae

Autores

CORRESPONSAL

M. del Pilar Sánchez-Saavedra

psanchez@cicese.mx

3

3

Departamento de Acuicultura, Centro de Investigación Científica y de Educación Superior de Ensenada, Carretera Tijuana-Ensenada #3918, Fraccionamiento Zona Playitas, Zip code 22860, Ensenada, Baja California, México

Duahmet A. Ruiz-Güereca

1

1

Departamento de Microbiología, Centro de Investigación Científica y de Educación Superior de Ensenada, Baja California, México

3

3

Departamento de Acuicultura, Centro de Investigación Científica y de Educación Superior de Ensenada, Carretera Tijuana-Ensenada #3918, Fraccionamiento Zona Playitas, Zip code 22860, Ensenada, Baja California, México

Alexei F. Licea-Navarro

2

2

Departamento de Innovación Biomédica, Centro de Investigación Científica y de Educación Superior de Ensenada, Baja California, México

Resumen

Tuberculosis is considered one of the most important epidemiological diseases worldwide. The current treatment for tuberculosis is a combination of antituberculosis drugs for at least 9 months. Nowadays, the search for new pharmacological agents for the treatment of tuberculosis is an urgent endeavor. Microalgae produce a wide variety of molecules that possess biological activities of pharmaceutical interest. Therefore, the objective of this work was to evaluate the antimycobacterial activity of hexane crude extracts of 6 microalgae: Chlamydomonas mexicana, Porphyridium cruentumIsochrysis galbanaRhodomonas sp., Aphanocapsa marina, and Nitzschia palea. All of the hexane extracts inhibited at least 90% of the growth of Mycobacterium tuberculosis H37Rv at a concentration of 100 μg ml-1. The hexane crude extract of I. galbana had the highest antimycobacterial activity displaying a percentage inhibition that was equal to that of the antituberculosis drug isoniazid and having a minimum inhibitory concentration of 50 μg ml-1. These findings demonstrate that microalgae are an excellent source for the search of novel antimycobacterial compounds.

Palabras clave

Tuberculosis, microalgae, crude extract, tetrazolium microplate assay, antimycobacterial activity

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